NATO aircraft scrambled from Romania following a large-scale Russian attack on across Ukraine overnight, including in the Odesa region near Danube River border with allied nation.

US president Donald Trump has suggested Ukraine should “fight back” to win against Russia in his latest fiery tirade on Truth Social, as he continues his attempts to broker peace between the warring nations.

Russia said Wednesday attempts to resolve security issues relating to Ukraine without Moscow's participation were a "road to nowhere," and that much diplomatic work needs to be done before Vladimir Putin and Volodymyr Zelenskyy are ever in the same room.

Russia struck an American business with cruise missiles overnight in one of the largest aerial attacks of the war so far, Ukraine has said.

Vladimir Putin is demanding that Ukraine give up all of the eastern Donbas region, renounce ambitions to join NATO, remain neutral and keep Western troops out of the country, three sources familiar with top-level Kremlin thinking told Reuters.

Nearly a week after President Trump’s Alaska summit, his suggestions of imminent breakthroughs have not come to pass.

As the front lines froze, and air defenses got better, Russia and Ukraine pivoted away from close bombing runs to standoff attacks.

Russia’s foreign minister has cast fresh doubt on peace talks, questioning “the legitimacy” of Ukrainian president Volodymyr Zelensky to sign any future agreements after targetting a US factory in a large bombardment on Ukraine.