Arizona Cardinals tight end Travis Vokolek was placed on a stretcher and taken off the field on a golf cart after injuring his neck on a kickoff return against the Indianapolis Colts.

Jacoby Brissett, filling in for the injured Kyler Murray, balled out in Week 6, giving the Cardinals their best offensive performance of the season as 2025 had been full of struggles with Murray under center.

Cardinals quarterback Kyler Murray is reportedly in danger of missing Week 6 — and possibly more — with a concerning mid-foot sprain believed to be "a version of a Lisfranc injury," per NFL Network.

Murray didn't play Sunday in Indianapolis, and backup Jacoby Brissett had a good game stepping in during the Colts' 31-27 win over the Cardinals. Brissett completed 27 of 44 pass attempts for 320 yards, two touchdowns and an interception.

The Arizona Cardinals again failed to seal the deal when it mattered in their Week 6 loss to the Indianapolis Colts, a game where the offense finally came alive but the defense had its worst outing of the season. Now, the Cardinals are losers of their last four games - all by a combined nine points.

Veteran backup Jacoby Brissett was the fill-in for Cardinals franchise quarterback Kyler Murray against the Indianapolis Colts after Murray’s ailing foot kept him out of action.

Off the rails is about the best way to describe the ending of the Arizona Cardinals' 22-21 loss to the Tennessee Titans in Week 5.

Arizona has now lost its last four games by a combined nine points, which offers some optimism that victory is not far away.

Anthony Richardson was inactive for Sunday's game against the Cardinals after sustaining an injury during pregame warmups. The Colts ' backup quarterback injured his eye while doing band work, according to NFL Network's Ian Rapoport.