When it comes to cancer, tumor suppressor genes are usually thought of as the "good guys." These genes make proteins that ...

Many cancers can be treated by administering DNA-damaging agents, such as platinum-based chemotherapy, because the resulting DNA damage causes the cancer cells to die. A subset of cancers, however, ...

The data showed elevated levels of the metabolite αKG improved DNA repair, and blocking it made the cancer cells more sensitive to treatment.

A new review highlights how human evolution has shaped the presence of pathogenic variations in DNA damage repair (DDR) genes, offering a new perspective on why modern populations face increased ...

Researchers found that cancer cells may repair chemotherapy-induced DNA damage, helping explain treatment resistance in ...

A protein best known for driving cancer growth also helps damaged tumor cells survive by repairing their DNA, according to a ...

Scientists have uncovered a surprising new trick used by one of cancer’s most notorious proteins. MYC, already infamous for ...

A new study suggests the APOE2 longevity gene may protect the brain from Alzheimer's by helping neurons repair DNA damage and ...