Vijay K. Kuchroo, PhD, DVM, of the Gene Lay Institute of Immunology and Inflammationof Brigham and Women’s Hospital, Massachusetts General Hospital and Harvard Medical School and the Ann Romney Center ...
T cells are the key immune system component involved in killing cancer. Tumors produce signals that turn off these T cells, partially by forcing them to progressively differentiate (mature) into a ...
This study, led by Dr. Panpan Jiang and collaborators at Tongji Medical College, explores the critical role of the Dedicator of Cytokinesis 8 (DOCK8) gene in the differentiation of helper T cells, ...
The Notch signaling pathway plays a pivotal role in determining cell fate, especially in the development and function of T cells. But mimicking this highly mechanical, contact-dependent pathway in the ...
(L to R) Co-first authors Peipei Zhou, Ph.D., Hao Shi, Ph.D. and corresponding author Hongbo Chi, Ph.D., all of the St. Jude Department of Immunology. T cells are used in adoptive cell therapy (ACT) ...
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