Dying cells are typically expelled from epithelial sheets to prevent foreign substances and microorganisms from entering, but the mechanism underlying this process is unclear. A recent study has ...

The field of mathematical modelling of calcium signalling dynamics has evolved into an essential interdisciplinary area that bridges applied mathematics, computational simulation and cell biology.

Inositol trisphosphate receptors (IP3Rs) are pivotal Ca²⁺ channels embedded in the membrane of the endoplasmic reticulum. Their activation by inositol 1,4,5-trisphosphate (IP3) and Ca²⁺ gives rise to ...

Scientists from Toronto's Princess Margaret Hospital are able to depict for the first time how an important molecule called IP3 and its receptor interact to control calcium levels in cells, a process ...

A molecule that had been thought to keep cell death at bay can actually play the Grim Reaper, report scientists based at the RIKEN Brain Science Institute. The death-dealing molecule, IRBIT, has been ...

Cerebral blood delivery depends on mechanisms such as electrical signaling, which propagates through capillary networks to upstream arterioles to deliver blood, and calcium signaling, which fine-tunes ...

It is vital to the regulation of cell activities through its role as a second messenger. Calcium signaling is the process whereby low cytoplasmic concentrations are deliberately increased to activate ...

Researchers discover a calcium-mediated effect that helps preserve the integrity of the sheets of cells lining our bodies and organs. Fukuoka, Japan—A research team from Kyushu University in Japan has ...