For simplicity's sake, it's easy to think of the genome as a set of instructions that cells use to create the proteins that they need. There are around 20,000 protein-coding genes in the human genome, ...

Joshua C. Snyder is in the Departments of Surgery and Cell Biology, Duke University School of Medicine, Durham, North Carolina 27710, USA. Marti-Solano and colleagues set out to determine how the ...

KRAS was one of the first oncogenes to be identified, a few decades ago. It is among the most common drivers of cancer and its mutations can be detected in around 25 per cent of human tumors. The ...

Our proteome is much bigger than our genome because one gene produces several variants of proteins called protein isoforms, whose disbalance is implicated in many diseases. A new bioengineered ...

New research led by the University of Exeter has shed light on the complexity of gene expression in the brain by characterizing the extent of isoform diversity in the human and mouse cortex, including ...

Increased demands for plasmid DNA (pDNA) for emerging nucleic acid-based vaccines and therapies exacerbate the need to remove bottlenecks from pDNA production. For industry, the problem has been that ...

ESPRESSO overcomes the limitations of error-prone long-read RNA sequencing, providing a useful resource to study transcriptome variation. Long-read RNA sequencing platforms could reveal variations in ...

Clinical and molecular characterization of urothelial (UC) vs. small cell carcinoma (SCC) of the urinary tract. Peripheral biomarker analysis in patients with advanced urothelial carcinoma (UC) after ...

Rather than representing a distinct gene product, this peptide arises from alternative splicing events within the IGF-1 gene locus, leading to a unique E-domain sequence with properties that diverge f ...

Treatment of advanced recurrent NSCLC with daily oral vinorelbine: A phase I trial. This is an ASCO Meeting Abstract from the 2013 ASCO Annual Meeting I. This abstract does not include a full text ...