Thousands of our cells successfully divide every day. They replicate their DNA and then separate so that each of the new cells has the same complement of chromosomes. If the process goes wrong and ...

In human cells, lengthy strands of DNA have to be carefully organized and compacted so they'll fit into the nucleus; our genome is arranged into chromosomes that have to be duplicated each time a cell ...

Two recent papers characterize a protein complex that is part of the budding yeast kinetochore, the specialization that links chromosomal DNA with one or more spindle microtubules. Both studies ...

During mitosis, replicated chromosomes are separated to daughter cells by the microtubule-based mitotic spindle. Chromosomes attach to the mitotic spindle through specialized DNA/protein structures ...

The kinetochore connects chromosomes to spindle microtubules, corrects attachment errors, and triggers the separation of sister chromatids. It is built from more than 100 proteins, grouped into around ...

This is a preview. Log in through your library . Abstract Previous efforts have shown that mutations in the Drosophila zw10 gene cause massive chromosome missegregation during mitotic divisions in ...

Crowning a quest into a very well-guarded secret: Structure of the kinetochore corona finally revealed Date: April 8, 2022 Source: Max Planck Institute of Molecular Physiology Summary: During cell ...

The cell cycle, the biological process underlying how cells grow and multiply, is tightly regulated to ensure a faithful distribution of genetic material to ‘daughter’ cells. This tight regulation of ...

In living organisms cells divide and reproduce in two ways, mitosis and meiosis. Mitosis results in two identical daughter cells, whereas meiosis results in four sex cells. During mitotic and meiotic ...

Cell division builds our bodies, supplying all cells in our tissues and organs, from the skin to the intestine, from the blood to the brain. It not only allows these organs to grow, but also to ...