Myosin-V processively walks on actin filaments in a hand-over-hand fashion. The identical structures of the heads predict a symmetric hand-over-hand mechanism where regular, unidirectional rotation ...

Certain smooth muscles are able to reduce energy consumption greatly when holding without shortening. For instance, this is the case with muscles surrounding blood vessels used for regulating blood ...

Myosin in muscles behaves in a unique way, which might explain why muscles have such strong contractile power. A cartoon showing the asymmetry in the weak binding between myosin and actin that biases ...

In a recent study published in Nature Communication, researchers employed artificial intelligence (AI)-driven virtual screening to discover 'F10', a novel cardiac-specific myosin inhibitor for ...