Figure 2: BILN 2061 inhibition of HCV polyprotein processing. Figure 3: BILN 2061 concentration in human plasma after single-dose oral administration. Figure 4: Antiviral efficacy of BILN 2061 in ...
Figure 1: Assay with optical tweezers for assessing the mechanistic cycle of NS3. To follow NS3-catalysed unwinding, we flow NS3 (1–90 nM) and ATP (0.05–1 mM) together in buffer U (see Methods). We ...
Thomas J. Chambers, Ronald C. Weir, Arash Grakoui, David W. McCourt, J. Fernando Bazan, Robert J. Fletterick, Charles M. Rice Proceedings of the National Academy of ...
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