Researchers have created the first complete map showing how hundreds of mutations in a key cancer gene affect tumor growth.

The DNA of Chernobyl cleanup workers and others exposed to high doses of radiation showed mutations that were also evident in ...

Study results indicate that mutation strength may shape both tumor–immune system interactions and immunotherapy response.

Patients with CaV2.1 channelopathies face severe and often debilitating symptoms, such as seizures, migraines, tremors, and ...

Every organism's genome contains mutations that often have unknown biological effects. In partnership with Stanford University, researchers at Charité—Universitätsmedizin Berlin have now discovered a ...

The androgen receptor is a key transcriptional factor for the proper sex development —specially in males— and the physiological balance of all the tissues that express this receptor. The androgen ...

In humans, hundreds of proteins interact in a complex network dubbed the interactome. Those interactions are further complicated when disease-causing mutations are introduced into genes that code for ...

Many people are familiar with histamine, a biological molecule that serves as a key driver of allergic reactions and other immune responses. However, histamine is also a major neurotransmitter in the ...

Researchers from Brigham and Women's Hospital (BWH) and the University of Murcia, Spain, have shed new light on why people who carry a common genetic mutation may be more at risk for developing type 2 ...