Understanding the structure of proteins is critical for demystifying their functions and developing drugs that target them. To that end, a team of researchers at Brown University has developed a way ...

Unfolded peptides and proteins exhibit a remarkable degree of structural diversity that defies the notion of a simple random coil. Recent investigations have elucidated that even in their so-called ...

GPCR dynamics, shown in purple as the human A 2A receptor, and elegant modifications in activation pathways (allostery) indicated by the blue arrow, are critical for enabling GPCRs to bind to multiple ...

Researchers from the Federal University of Para, Brazil, presented a systematic analysis of the affinity and conformational dynamics between the binding of severe acute respiratory syndrome ...

Novel protein cage system can control and visualize orientational changes in aromatic side chains upon ligand binding, as reported by researchers at Institute of Science Tokyo. By inducing coordinated ...

Acyl carrier protein (ACP) plays a central role in fatty acid biosynthesis, acting as a molecular "shuttle" that carries, protects, and delivers elongating acyl chains to various enzymatic partners.

Adaptor protein (AP) complexes play central roles in intracellular vesicular trafficking by coupling cargo selection to vesicle formation. AP-4, an important member of the AP family, plays a key role ...

A newly developed generative AI model is helping researchers explore protein dynamics with increased speed. The deep learning system, called BioEmu, predicts the full range of conformations a protein ...

Both the severe acute respiratory syndrome coronavirus 1 (SARS-CoV-1) and SARS-CoV-2 have led to the SARS epidemic and coronavirus disease 2019 (COVID-19) pandemic, respectively, within the last two ...