Open-access databases such as the European Nucleotide Archive (ENA) contain more than 2.4 million bacterial genomes, and this number continues to grow rapidly. Until now, searching these vast ...

Multiple sequence alignment (MSA) lies at the heart of comparative genomics, structural biology and evolutionary inference. By arranging three or more nucleotide or amino acid sequences in a matrix, ...

Computational protein design has emerged as a powerful tool for rational protein design, enabling significant achievements in the engineering of therapeutics 1,2,3, biosensors 4,5,6, enzymes 7,8, and ...