Explore the role of transcription factor biology in drug discovery and how it impacts our understanding of disease mechanisms ...

Transcription factors are an essential part of gene expression. Some of these proteins are known as master regulators, and they can have an impact on many different biochemical pathways and processes ...

Scientists used the auxin-inducible degron 2 system on CTCF, bringing the novel approach to bear on a fundamental protein. CTCF is a critical protein known to play various roles in key biological ...

The field of cancer epigenetics examines how heritable changes in gene regulation - independent of DNA sequence - impact ...

Some things just go together like “rock and roll” and “fish and chips” or, in molecular biology, “transcription factors” and the “nearby genes they regulate.” The standard, simplified story goes like ...

During viral reproduction, the influenza polymerase (top left, in blue) scans along the ribonucleoprotein helix to produce messenger RNA. Credit: Science Like a camera-shy teenager, influenza’s ...

(Memphis, Tenn.—January 25, 2023) CTCF is a critical protein known to play various roles in key biological processes such as transcription. Scientists at St. Jude Children’s Research Hospital used a ...