Around 2015, Katherine Chiappinelli was investigating the mechanism behind a group of drugs approved to treat blood cancers—and showing promise against other cancers—when she made a puzzling discovery ...

New research from Washington University School of Medicine in St. Louis suggests that transposable elements in various cancers potentially may be used to harness novel immunotherapies against tumors ...

New research from scientists at Cleveland Clinic’s Genome Center and their collaborators at other institutions describes a pathway that human herpes simplex-1 (HSV-1) can use to contribute to the ...

New research suggests that transposable elements in various cancers potentially may be used to direct novel immunotherapies to tumors that don't typically respond to immune-based treatments. Jumping ...

In healthy cells, transposable elements (TEs) are typically inactivated by methylation. But in cancer cells, these elements can become demethylated, enabling them to be expressed (1). Some ...

The human genome, an intricate tapestry of genetic information for life, has proven to be a treasure trove of strange features. Among them are segments of DNA that can "jump around" and move within ...

Regarded historically as genomic parasites, transposable elements (TEs) have now been recognized as significant contributors to cellular identity and function, especially in immune regulation.

A key protein network that keeps cells safe from dangerous genes has been uncovered. A research team from La Jolla Institute for Immunology (CA, USA), The University of Queensland (Brisbane, Australia ...