New research has identified that neuroinflammation driven by microglia (immune cells in the brain) is a primary underlying ...

FDG PET imaging measures glucose uptake in the brain. It has long served as a proxy for neuronal health—but is it? In the October 13 Science Translational Medicine, researchers led by Christian Haass ...

Multiple sclerosis (MS) is one of the most progressive autoimmune diseases that affect the central nervous system where the immune system attacks the myelin sheath that covers the nerve fibers and ...

“This is a paradigm shift,” says Donn Van Deren, PhD, postdoctoral research fellow at the University of Pennsylvania, who conducted the research while working in human genetics at the University of ...

Examining post-mortem tissue from the brains of people with Alzheimer's disease, Stanford University School of Medicine investigators identified what appear to be iron-containing microglia -- ...

In chronic neurodegeneration associated with prion disease, reactive microglia adopt a highly mobile, neuron-by-neuron surveillance strategy, replacing homeostatic process-based monitoring with ...

A rare coding variant of Abi3 increases risk of AD. Knocking out Abi3 increases Aβ accumulation, neuroinflammation in mice. Abi3 knockout microglia were DAM-like in their gene expression, but ...

Researchers at Karolinska Institutet have discovered that the nervous system's own immune cells help protect the spinal cord from age-related damage.