New hifiasm-ONT assembly method delivers high-quality, cost-efficient near T2T assemblies using standard Oxford Nanopore Simplex reads, broadening access to comprehensive genome assemblies across ...

The mission to improve the widely used simplex-method algorithm showed instead why it works so well.

Compared with Levenberg Marquardt, the local and initial value sensitive algorithm, Simplex, a global algorithm, is the only robust and easy method which is irrelevant to initial input value.

New hifiasm-ONT assembly method delivers high-quality, cost-efficient near T2T assemblies using standard Oxford Nanopore Simplex reads, broadening access to comprehensive genome assemblies across ...

MIT, Cambridge] and the original simplex method with the most-negative-reduced-cost pivoting rule of Dantzig are strongly polynomial-time algorithms for solving the Markov decision problem (MDP) with ...

OXFORD, England, April 18, 2025--A new paper, released this week on bioRxiv, introduces hifiasm-ONT, a breakthrough genome assembly algorithm that enables partially phased, near telomere-to-telomere ...