Course TopicsPower analyses and sample size calculations are important parts of many research projects. Often, before data are even collected, it is necessary to calculate and justify the required ...

In this article, we describe two tests for the case-cohort design, which can be treated as a natural generalization of log-rank test in the full cohort design. We derive an explicit form for ...

Larger sample sizes not only increase the power of achieving trial objectives but also increase trial cost and duration. Despite flourishing literature in novel dose-finding designs, only a limited ...

Course TopicsPower analyses and sample size calculations are important parts of many research projects. Often, before data are even collected, it is necessary to calculate and justify the required ...

Our sample size formula includes several existing formulas as special cases when the working variance function is correctly specified as the true variance function. We also consider a sensitivity ...