Another mode of activation is the mannan-binding lectin pathway (MB-lectin pathway). That is initiated by binding of the serum protein mannan-binding lectin to mannose-containing carbohydrates on ...

After a slow start, the race is on to inhibit key proteins and pathways within the complement system -- a biological cascade that is central to the innate immune system and many different diseases ...

The "dextran" in superparamagnetic dextran iron oxide nanoworms is a sugar that is recognized by the lectin pathway, activating the complement system and resulting in the immune system attacking ...

Omeros’ OMS721 is a human monoclonal antibody that inhibits MASP-2, which is the effector enzyme of the lectin pathway of the complement system.

Mannose-binding lectin and the lectin complement pathway evolved well before antibodies and are often considered to be proto-antibodies.

These findings suggest complement protein levels may be an important biomarker for type 1 diabetes. Disruption of the complement system appears to precede the onset of islet autoimmunity (IA ...

Activation of the complement system is typically thought to occur through three pathways: the lectin pathway, which is triggered by carbohydrates on cell surfaces; the classical pathway, which ...

Three pathways have now been described in the complement system — the classic, alternative and lectin. A fourth, lytic pathway is added by some authors for membrane attack complex.

The complement system can be activated through the following three distinct pathways: the classical, lectin and alternative.

Activation of the complement system through the alternative pathway is necessary for the development of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) in animal models C5a ...

Omeros Announces Publication of Study Showing that Inhibition of MASP-2, the Key Enzyme of the Complement System’s Lectin Pathway, Protects Against Renal Injury Caused by Proteinuria ...

Complement inhibition is the best approach to managing PNH, in that PNH-related hemolysis is modulated in large part by the alternative complement pathway, which acts as a amplification loop for ...