I have a Monoprice 8x6 tablet I got the other year. It worked fine. Then I had to reinstall windows and now I've just had headaches getting it working again. It did not come with an install CD ...

Wacom tablet 4.72-3 is an updated driver for all Wacom USB tablets. [OS 9 & OS X] Update: ...

But with a good open source driver it should be possible to port most Linux-based operating systems, complete with support for hardware accelerated graphics.