Note: This story contains spoilers from "The Twisted Tale of Amanda Knox" Episode 2. "The Twisted Tale of Amanda Knox" plunges viewers into the "psychological nightmare" that befell Knox when she was accused of killing her roommate Meredith Kercher while studying abroad in Italy in 2007 and was subsequently wrongfully imprisoned for years.

Van Patten tells PEOPLE she remembers worrying, "What would [Knox] think of me, this random actress portraying her in a very traumatic time of her life?"

"The Twisted Tale of Amanda Knox" premieres on Hulu on Wednesday, Aug. 20 with its first two episodes and will air weekly until the finale on Oct. 1.