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Pancreatic cancer arises when cells in the pancreas mutate and multiply uncontrollably, forming a tumor. Risk factors include smoking, obesity, family history, certain genetic syndromes, diabetes, chronic pancreatitis, and age (most cases occur in people over 65). Unfortunately, symptoms often don't manifest until the cancer has advanced, contributing to its high mortality rate. Diagnosis typically involves imaging tests, biopsies, and blood tests to assess pancreatic function and detect tumor m
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Pancreatic cancer is one of the deadliest cancers, with a five-year survival rate of less than 10%. Unlike many other cancers, which are often detected early and treated successfully, pancreatic cancer is usually diagnosed at an advanced stage when treatment options are limited. This is partly because of its dense, fibrotic barrier. A stiff matrix of collagen and connective tissue surrounds cancer cells, creating a scar-like shell, known as the tumor stroma, that physically blocks drugs from pen
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