#BCIS What is Bone Cement Implantation syndrome ? Answer BCIS is characterized by hypoxia, hypotension or both and/or unexpected loss of consciousness occurring around the time of cementation, prosthesis insertion, reduction of the joint or, occasionally, limb tourniquet deflation in a patient undergoing cemented bone surgery. Proposed severity classification of bone cement implantation syndrome Grade 1: moderate hypoxia (SpO2 20%]. Grade 2: severe hypoxia (SpO2 40%) or unexpected loss of consci