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The shapes of cell nuclei can help doctors diagnose diseases ranging from cancers to blood disorders. A new technique called expansion in situ genome sequencing (ExIGS) from Ajay Labade, Zachary Chiang, Caroline Comenho, Fei Chen, Jason Buenrostro, and others is now expanding the amount of information researchers can extract from individual nuclei. ExIGS — a combination of in situ sequencing and expansion microscopy — allows scientists to sequence DNA and map its location relative to nuclear pro
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